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研究人员发现有望治疗银屑病的化合物

2018-04-23 15:31:02    新华网

新华社华盛顿4月22日电(记者周舟)美国和俄罗斯等国研究人员日前在英国《自然》杂志网络版上发表研究报告说,从免疫细胞提取的一种化合物可抑制炎症反应,有望治疗银屑病和其他自身免疫性疾病。

银屑病俗称牛皮癣,是一种常见的慢性炎症性皮肤病,表现为红斑、银屑和瘙痒。

论文通讯作者、美国华盛顿大学的马克西姆·阿尔乔莫夫介绍说,抗炎能力也会在免疫系统伤害自身时发挥作用。阿尔乔莫夫团队此前发现细菌入侵后,炎症细胞会产生名为衣康酸的化合物,这种化合物可以抑制炎症反应,而不是增强炎症反应。

在本次研究中,研究人员利用衣康酸二甲酯治疗小鼠和人类的炎症细胞,发现这种化合物可以降低白细胞介素-17炎症通道中一种关键蛋白质“IkB-泽塔”的水平。这一通道可抵御病毒感染,但也是诱发自身免疫性疾病的主要通道。

研究人员分析了银屑病患者的基因后发现,负责编码“IkB-泽塔”蛋白质的基因发生变异与银屑病风险升高存在关联。

研究人员在两组小鼠耳朵上促发银屑病,然后每天给两组小鼠分别注射衣康酸二甲酯和安慰剂。一周后,注射安慰剂的小鼠耳部红肿,而注射衣康酸二甲酯的小鼠则没有表现出症状。

研究人员说,白细胞介素-17炎症通道在多发性硬化症、类风湿关节炎、红斑狼疮等多种自身免疫性疾病中都发挥作用,因此抑制这一通道有望对这些疾病也产生疗效。

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