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超级细菌逃逸机制揭示

2018-12-04 06:37:04   科技日报 

科技日报北京12月2日电(记者张梦然)据英国《自然》杂志近日发表的一项医学研究成果,一个国际研究小组最新发现,一种蛋白质能够成为超级细菌的“隐身斗篷”,帮助耐甲氧西林金黄色葡萄球菌躲避人体免疫系统的识别和攻击。该发现为未来治疗细菌感染提供了新靶点。

超级细菌被认为是全球医疗健康领域最具挑战性的目标之一,几乎让人类陷入了无药可用的窘境。超级细菌指那些对多种传统抗生素具有耐药性的细菌,其中,耐甲氧西林金黄色葡萄球菌是较常见的一种,也是具有潜在致命性的一种。幸运的是,它们虽然对抗生素有耐药性,但在人体内仍然会受到免疫系统的攻击。

然而,此前的研究显示,超级细菌除了顽强,还兼有“与时俱进”的能力——它们中的一些已经能躲避免疫系统的攻击,也正由于此,治疗它们引起的感染越来越困难。

此次,德国马克斯·普朗克胶体与界面研究所领导的一个国际团队报告称,他们在耐甲氧西林金黄色葡萄球菌上发现了一种先前未知的蛋白质,并将它命名为TarP。研究人员介绍,这种蛋白质可起到类似“隐身斗篷”的作用,正是它使耐甲氧西林金黄色葡萄球菌不被人类免疫系统发现,也让免疫系统无法产生针对这种细菌的抗体。

研究人员认为,这一发现意味着未来可以将这种蛋白质作为治疗细菌感染的新靶点,开发抑制其功能的药物,从而使耐甲氧西林金黄色葡萄球菌等病原体,在人体免疫系统面前“原形毕露”,进而被免疫系统识别和攻击。

责任编辑:路子康 CN078
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