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强生研制出HIV疫苗? 专家解读:只是初步阶段

2017-08-10 17:33:42   央广网

尽管强生的艾滋病疫苗还在路上,但资本市场已经迫不及待的炒作相关概念股了。作为强生抗艾滋病、抗糖尿病以及中枢神经镇痛等商业化上市创新药的主力供应商,博腾股份继续上涨,实现八连涨。甚至在昨天消息出来时,股价一度涨停。公司年报显示已经成功进入强生的多个高潜力临床二期、临床三期抗癌、抗病毒药物的研发产品管线。不过今天公司相关负责人告诉记者,博腾股份只是强生抗艾滋化学药合作商,这次的实验并没有参与。

负责人说:“化学药也有很多核心的抗艾滋的产品,这个我们是有跟他合作的。他有一款上市很多年的抗艾滋的化学药,是一个很老的也是很重要的抗艾滋的产品,这一款我们是一直有合作的。”

目前治疗艾滋病的疫苗主要分为化学制剂疫苗和生物制剂疫苗两种,既然有了化学药物,强生为何又在生物药领域重头再来?成都先导药物开发有限公司高级总监万金桥博士解释,化学药物指标不能治本,想要治本还得靠生物药。

万金桥说:“就艾滋病毒来讲,用化学的方法来控制是没问题的,但是如果想把病毒完全清除掉,用化学的方法基本上是不可能做到的。因为艾滋病毒的特点就是会整合到人体自身细胞的基因组中,对于这种病毒来说,生物制剂比较有希望。”

既然生物药能治本,为什么起初强生不直接研发生物药,而是走了化学药的弯路?万金桥解释到,因为化学药生产成本更低,而生物药生产成本和使用成本过高。

万金桥博士分析:“整体来说,生物制剂肯定会占的比重越来越大,尤其是在中国。生物制剂相对来说研发周期要比化学制剂短,它的效果比较好,不需要解决太多畸形等方面的问题。但实际上生物制剂在后期生产和使用上的成本是很难降下来的。化学制剂的研发周期比较长,但一旦新药上市之后,它的生产成本相对来说是比较低的。专利期一过,化学药的价格会很便宜,甚至十分之一都不到。”

博腾股份也告诉记者,目前他们也正考虑在生物药方面投入,与强生等公司继续开展深入合作。

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