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艾滋病疫苗研制成功? 系部分媒体和公众误读
2017-08-14 14:11:57 中国经济网
所以,这次“APPROACH”艾滋病疫苗临床试验所产生的“免疫应答”已经存在,但这种“免疫应答”能否有效抗击外来艾滋病病毒的入侵,保护人体健康,目前尚无法知道,还需要进一步大量的临床研究。
混淆了临床前研究和临床研究
另外,媒体还公布了一部分“吸人眼球”的数据:“受试者单次暴露于艾滋病病毒(HIV)下感染风险减少了94%,并且有66%的受试者在6次暴露于HIV之下仍然得到了有效的保护,没有被HIV感染。”
“但遗憾的是,这部分数据并非人体临床试验获得,而是来自于对动物模型猴子的‘临床前’研究结果。”姜天俊表示,正确的表述应该是:在之前该疫苗进行的一项动物实验(猴子)中,其中一组有效接种方案将单次暴露于SHIV的感染风险降低了94%,6次暴露后仍然有66%的动物没有被SHIV感染。这里需要一提的是,SHIV并不是HIV,而是一种猴免疫缺陷病毒(simian immunodeficiency virus,SIV)与人免疫缺陷病毒(human immunodeficiency virus,HIV)的重组病毒,能避免SIV感染并不一定能免遭HIV感染;猴子能避免感染也并不预示着人类就可以避免感染。
对于媒体的“热情”解读,强生公司相关负责人在接受记者采访时表示,媒体翻译存在失误。降低感染风险这个结果是从临床前的动物研究中得出的,但是某些中文媒体却当成了临床研究,严重夸大了这个结果的意义。“其实,这就是一个研究阶段的进展,显示了乐观的前景。”对此,该负责人很无奈。在姜天俊看来,艾滋病疫苗离上市也还很遥远。(记者 李颖)
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