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3国际团队重复韩春雨实验失败 自然明年结束调查

2016-11-29 10:50:09   澎湃

《自然-生物技术》还发表了一篇“编辑部关注”,用来“提醒读者对原论文结果(韩春雨课题组论文)的可重复性存有担忧”。当地时间11月28日,英国国际期刊《自然-生物技术》在线发表了德国弗莱堡大学医学中心细胞与基因治疗研究所负责人ToniCathomen及同事针对韩春雨课题组的NgAgo基因编辑技术的评论通信文章,表示利用NgAgo技术未能检测到DNA引导的基因组编辑。同时,《自然-生物技术》还发表了一篇“编辑部关注”,用来“提醒读者对原论文结果(韩春雨课题组论文)的可重复性存有担忧”。

《自然-生物技术》表示:“今天,我们不仅发表了Cathomen及同事的通信文章,这可能会否定原论文所称的有效编辑内源性基因的这一主要发现”。

此次在《自然-生物技术》发表评论通信文章的来自全球三个团队:美国明尼苏达大学生物化学与分子生物学系教授Stephen C Ekker团队、德国弗莱堡大学医学中心细胞与基因治疗研究所负责人Toni Cathomen团队、韩国基础科学研究所基因编辑中心Jin-Soo Kim团队。他们都设法去重复韩春雨及同事发表在原论文中图4的结果,这一关键图表展示了对哺乳动物细胞内源性基因位点的编辑。这些团队无一能在任何位点,或在任何高于检测方法敏感度的条件下观察到NgAgo所诱发的变异。

在《自然-生物技术》给澎湃新闻的一份《关于“利用NgAgo进行DNA引导的基因组编辑”的最新声明》中,《自然-生物技术》表示:“让原作者在能力所及的情况下对上述通信文章所提出的担忧展开调查,并补充信息和证据来给原论文提供依据是非常重要的。因此,我们将继续与原论文的作者保持联系,并为他们提供机会,以在2017年1月底之前完成其调查。届时,我们会向公众公布最新进展。”

同时,声明中提到:“在任何情况下,如果一篇论文在发表后遭到批评,我们都会对各种批评进行审慎和全面的评估,此次也不例外。”

《自然-生物技术》透露,它向韩春雨课题组的所有作者通知了自己将发表编辑部关注,通讯作者韩春雨和第二作者沈啸表示同意,而第一作者高峰、第三作者姜峰、第四作者武永强认为并不合适。

《自然-生物技术》表示:“我们和论文作者进行了沟通,他们正在调查造成可重复性缺乏的潜在原因。我们向其告知了这一声明。尽管调查仍在进行中,但韩春雨和沈啸同意我们发表的这一编辑部关注,高峰、姜峰和 Yongqiang Wu则认为目前并不合适。这些调查一旦完成,我们会向读者提供最新信息。”

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