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河北"三无"副教授诺奖级论文遭质疑:实验无法重复

2016-08-01 08:32:06   新京报

河北科技大学副教授韩春雨在实验室。河北科技大学官网截图

由于多位科学家称未能重复实验结果,曾在国际期刊发表论文的河北科技大学副教授韩春雨受到质疑。昨日,他告诉记者,并不会回复这些质疑,并认为质疑“不科学”,实验结果的讨论还得回归科学本身。

韩春雨被称为“三无”副教授:无名校(非985非211的河北科技大学)身份、无名气(名不见经传,几乎没有任何人才头衔称号)、无职位(无行政职位),他的实验室也简陋得令人惊讶。

实验结果无法重复遭质疑

由于实验结果无法重复,韩春雨发表在世界顶级期刊的实验结果遭受质疑。此前曾称已重复实验成功的澳大利亚国立大学医学、生物和环境学院教授盖坦·巴尔焦发表博客称,经过多次尝试,仍未重复出韩春雨的结果。

据了解,2016年5月2日,韩春雨课题组的论文《DNA-guided genome editing using the NatronobacteriumgregoryiArgonaute》在《自然-生物技术》杂志在线发表。论文内容大致为,以DNA来介导NgAgo(一种核酸内切酶)对靶向基因的识别从而进行基因编辑,被认为是基因编辑领域的重大突破。

博客中,巴尔焦说,他仍未发现任何证据证明NgAgo能进行基因组编辑。他甚至得到相矛盾的结果。韩春雨的文章称NgAgo在37℃以上的实验条件下起作用,但巴尔焦的实验结果却为50℃。

与此同时,国际转基因技术协会(ISTT)在其Twitter上推送数位科学家的实名评论,其均无法重复实验结果。

前普林斯顿大学教授、现就职于美国霍华德休斯医学研究所(HHMI)下属研究机构Janelia Farm的科学家David Stern说,无法利用NgAgo在果蝇中进行编辑。

另一位西班牙科学家LluisMontoliu则称,他们曾在韩春雨之前利用相关内切酶进行两年的实验,并无法实现基因组编辑。

对此,韩春雨昨日告诉记者,目前的质疑并“不科学”,实验结果的讨论还得回归科学本身。

多国科学家呼吁自然杂志介入

两个月来,尚未有科研团队重复出韩春雨实验结果。随后,多国科学家公开建议《自然-生物技术》介入,要求韩春雨公开原始数据。

国际转基因技术协会原主席路易斯·蒙特柳曾对媒体回应,从6月末至7月初,多个实验室分别利用人类、老鼠或是斑马鱼的细胞重复实验,但均以失败告终。

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