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韩春雨诺奖级技术争议升级 方舟子指其论文造假

2016-07-31 18:03:30   观察者网

韩春雨诺奖级技术争议升级 方舟子指其论文造假

韩春雨诺奖级技术争议升级 方舟子指其论文造假1

一直默默无闻的河北科技大学副教授韩春雨,恐怕不会想到,自己成了2016年生物学界的焦点人物之一。

从被部分媒体捧为“中国下一个诺奖获得者”,到陷入国际性的学术造假争议,虽然韩春雨本人基本保持低调,但围绕他及其新基因编辑技术NgAgo的风暴却越演越烈。

较早将这一学术争议引入大众视线的方舟子,则在今天31日上午,直指韩春雨博士学位论文造假。

新一轮国际风暴

韩春雨的NgAgo基因编辑技术,被认为有潜力取代目前的CRISPR技术,在国际上引发了一定的反响,并被部分国内媒体称为“诺奖级”技术。

然而,数月以来,全球科学家几乎都没能重复他的实验结果,同行的质疑声越来越强烈。

直到7月29日,“友军”的倒戈引发了新一轮国际风暴。

澳大利亚国立大学的法国基因学家Gaetan Burgio,曾凭间接证据宣称重复韩春雨的结果,非常高效。这一度让韩春雨的支持者看到了希望,但Gaetan Burgio谨慎地表示要等待基因测序的直接结果。

29日,Gaetan Burgio发布长文最终否定了先前的结论,表示在多种细胞上反复尝试后,没有发现证据能够真正证明NgAgo发生基因编辑。

而且,他还质疑如果不把NgAgo内切酶加热到50摄氏度,让其保持在37摄氏度的话是否会有活性。

Gaetan Burgio说,“《自然生物技术》期刊应该要求韩春雨公开所有的原始数据和实验条件……NgAgo的未来并不明朗。”

很快,国际转基因技术协会(ISTT)代表其前主席Lluis Montoliu群发邮件,公开质疑韩春雨,呼吁“同事们”不要再浪费时间、金钱、人力和课题,并在文末并高呼“CRISPR万岁”(Long Life to CRISPR)。

“目前最需要传递的信息是,NgAgo在哺乳类细胞中不会进行基因编辑。为了科学的开放性,如果任何人获得了正面线索,请共享结果。”

Lluis Montoliu本人也呼吁韩春雨公布原始数据和实验条件。

30日,方舟子转引了ISTT邮件,并指出:“针对该技术调查表明,140个回复中,只有一个(中国神经所仇子龙?)回答有效,73个无效,63个在验证。”

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