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小鼠研究显示剖宫产孩子或更易肥胖

2017-10-14 11:26:53   

新华社华盛顿10月13日电(记者林小春)据美国《科学进展》杂志近日发表的一项新研究,小鼠实验表明,与自然分娩相比,剖宫产可能更易导致孩子肥胖,而这可能是肠道菌群惹的祸。

为了解剖宫产对后代早期发育时体重增加的影响,纽约大学医学院玛丽亚·多明格斯-贝尔等人比较研究了34只经剖宫产出生的小鼠和35只自然分娩的小鼠,定期记录它们的体重,并通过基因组学技术分析它们从出生到成年期肠道菌群的变化。

结果显示,剖宫产小鼠断奶后15周的体重会比顺产小鼠高33%,其中剖宫产雌性小鼠比顺产雌性小鼠体重高出70%,表明体重增加过快问题在雌性身上更为明显。

相对应的是,剖宫产小鼠肠道菌群与顺产小鼠有明显不同,不过这种差异不分性别。顺产小鼠的肠道菌群构成会随着小鼠长大而正常成熟;但剖宫产小鼠的肠道菌群构成起初成熟过快,但后来会变得相对不成熟。

多明格斯-贝尔说,这项研究首次表明了剖宫产与哺乳动物体重增加存在因果关系,也显示在自然分娩过程中,母亲会把可阻止孩子体重增加过快的菌群传给后代。

研究人员指出,人类10%到15%的分娩需要用剖宫产,以避免母婴生命受到威胁,但这种救命手术常常被滥用,某些地区40%以上的准妈妈们使用剖宫产。

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