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重大突破:一滴血可测癌症,已被批准临床使用(图)

2017-05-01 14:35:47   新华网

这位癌症患者说:到了9月份的时候又做了一次,这次距离手术已经有9个月了,这个时候其他的情况都还显示是正常的。像CE1、Ca125肿瘤标志物,这些都是正常的,但是90α就到了100多、120几的样子。这个不正常。

除了热休克蛋白90α的数值异常,别的肿瘤标志物都显示正常,再加上没有别的反应,使这位患者并未引起太大的重视。但令他没想到的是,到了2015年,其他的肿瘤标志物指标也不正常了。

癌症患者:一直到了2015年,这个时候CT已经明显出问题了,体感也能够感觉到不好的感觉。后来,这个时候开始吃药。当时是在CT和其他几个提前半年,90a反映出来的,如果我当时有这方面的知识,应该警觉,早一点干预。

眼下,经过积极治疗,这位患者的病情已经得到控制。运用多种手段检测身体的变化,成为了他的必修课。

癌症患者:到了2016年6月份,90a又降到60几,因为CT显示也不错。

临床数据表明,在肺癌中,传统的肿瘤标志物CEA灵敏度只有54%,符合率为66%;而热休克蛋白90α的灵敏度达到72%,符合率为75%,明显优于CEA。而在肝癌中,传统的标志物AFP灵敏度为53%,符合率为74%;热休克蛋白90α的灵敏度达到93%,符合率为92%。

天津市人民医院肿瘤研究所所长王华庆说:热休克蛋白90α在基础实验当中以及已经开展的在非小细胞肺癌、在肝癌中,已经发现它大大优于目前我们临床上常用的这些标志物。

在稳步推进肺癌、肝癌检测的同时,罗永章团队还在积极试验热休克蛋白90α检测其它癌症的可行性。目前,普罗吉公司的内部试验数据显示,热休克蛋白90α在弥漫性大B细胞淋巴瘤上的灵敏度,达到了73%。

王华庆说:在淋巴血液系统,就是我所从事的恶性淋巴瘤的研究当中,在基础实验也有了非常好的苗头。它又敏感、特异性又高。我们觉得这个无疑是一个重大的发现。那么,由我们中国人牵头开展这样的研究,不仅是对我们中国有利,而且对世界范围内,在癌症的早诊早治,能作出我们的贡献,我们觉得它价值非常大。

热休克蛋白90α检测肝癌、肺癌的有效性已经在临床得到充分验证,对于其它癌症检测的有效性试验也在稳步推进。在外人看来,热休克蛋白90α应用前景应该是一片光明,而崔大伟却认为,好日子还远远没有到来。眼下,虽然热休克蛋白90α检测技术获得了国家许可,但是推广的时间比较短,销量并不大。普罗吉的烟台工厂,常常是“三天打渔,两天晒网”。

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