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韩春雨:已有6、7家实验室重复出关键环节

2016-08-12 08:55:54   观察者网

Jan Winter说自己将完全按照更新的实验细节,再做一次实验。澳大利亚国立大学盖坦·布尔焦则认为,该版本相较于论文中已提供的实验数据,没有增加太多内容。一位不愿具名的学者评论说:“不认为这有多大帮助。没有什么特别的。”

8月10日下午,《自然》杂志工作人员回复媒体称,韩春雨未将该版本实验细节提交给《自然》,暂无可以对外公开的调查进展。

国家下拨300万元专项研究资金

在多种场合下,韩春雨承认的一点是,NgAgo现在还不稳定,需要优化改善。但他不能等到技术优化了之后再发表论文,“这是科学发现,竞争非常厉害。”他举例说CRISPR在刚问世时,效率也不到1%,都是慢慢改进的过程。

但外界没有太大耐心,从6月开始,无法重复NgAgo实验的反馈越来越多。

韩春雨反而觉得在论文发表后1个月就出现质疑声,这不科学。他说:“如果他们确定是假的,根本不用炒作,过段时间做不出来,到时候《Nature》要求撤稿,它也就不为所动了。为什么要这么迫不及待的?1个月能看出什么来,实验还没做完一轮呢。”

盖坦·布尔焦告诉澎湃新闻,做完一次完整的NgAgo实验至少需要2-3个月。Jan Winter则表示,就他而言,全职做实验可在一个月内完成。

自5月论文发表后,韩春雨开始经常收到恐吓电话和短信,多则一天几十个。一些传闻也开始出现,网传他因为NgAgo论文的发表,破格升为教授,还有上亿元科研资金入账。当澎湃新闻向河北科技大学学科建设办公室副主任罗湘南确认这些传闻时,她说都不属实。

“之所以弄成这样,是因为它有价值”,韩春雨说。基因编辑技术在治疗人类疾病上有不错的发展前景。若真如论文中所说的高效,NgAgo或将成为继CRISPR-Cas9之后的第四代基因编辑技术,这意味着,NgAgo有可能成为瓜分基因编辑这块商业沃土的一份子,在一定程度上和同类技术存在利益冲突。

“你想想它动的谁的蛋糕最大,其次动的谁的蛋糕最大”,韩春雨说,“然后动了谁的蛋糕,你就会比较清楚了。”

韩春雨反复提及的一件事是,美籍华人科学家张锋和詹妮弗·杜德纳争夺CRISPR-cas9专利的官司,背后牵扯到数千万美元的利益。他还从微信群聊记录里翻出一条新闻,国外一家研究CRISPR的公司已经拿到3800万美元B轮融资。

“你想,CRISPR(注:第三代基因编辑技术)出来,TALEN(注:第二代基因编辑技术)就没有市场了。TALEN还成功治愈了一例白血病了。没有CRISPR的话,TALEN的市场将是上百亿美金。”韩春雨说。

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