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有超级抗生素可以战胜超级细菌“飽曼不动杆菌”?

2017-08-25 19:40:59   中国经济网

而头孢哌酮/舒巴坦则不能透过血脑屏障,治疗颅内感染需鞘内注射。另外,由于碳青霉烯类药物(除比阿培南外)均有中枢毒性,所以由鲍曼不动杆菌等耐药菌引起的颅内感染临床上可供选择的治疗方案已经不多。头孢噻肟/舒巴坦、头孢曲松/舒巴坦在此治疗领域对防治鲍曼不动杆菌是非常有效的,也给医生和病人带来非常大的益处。

由于头孢曲松舒巴坦、头孢噻肟舒巴坦、哌拉西林舒巴坦(2:1)等疗效确切,副作用更少,安全性高,得到医护工作者的广泛认同。该药是中国药科大学与HWM.Co合作创新的重大科研项目、发明专利,是我国自主研发的Ⅰ类新药,具有更高疗效的抗耐药抗生素。据国际著名的IMS预测,随着FDA和欧盟加快批准,在国际和国内市场将成为抗耐药抗生素的一线药物。

该用的药必须用,但不能滥用

自20世纪末,头孢哌酮舒巴坦进入全国医保目录和各省医保目录,以及国内重点城市公立医院畅销药物排名榜,呈现出快速增长态势,随后几年表现尤为突出,市场走势一路上扬。2010年,公立三甲医院头孢哌酮舒巴坦的购药金额已达到4.66亿元。

迄今为止,国内头孢哌酮舒巴坦仍是复方抗耐药抗生素市场居首位药物。但由于头孢哌酮舒巴坦长期大量、大面积使用,造成该药对鲍曼不动杆菌的耐药率达到了43%。

治病救命,该用的药必须用,但不能滥用。

我国《抗菌药物临床应用管理办法》正式实施后,促进了抗菌药物的合理、规范使用,因为抗菌药物在临床上具有不可替代的作用,目前是全世界所有药物中疗效和治愈作用最为明确、最大类的药物,医生及时、对症、合理、足量使用是最为有效的管理办法,也是对患者对生命极大的负责。

对此,原中华医学会会长著名呼吸病专家钟南山院士曾呼吁,应“合理用药,预防不动杆菌耐药”。

专家指出,由于鲍曼不动杆菌的自身特点,鲍曼不动杆菌感染诊治和防控仍有许多问题没有解决,需要广大医护的积极探索,积累经验和循证医学证据,不断完善共识。

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