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1996年,开始了猪胰岛移植研究,在上百批次地在小白鼠身上进行试验获得成功,标志着胰岛移植确实可以治疗糖尿病。
1998年,在猴体身上开展了移植猪胰岛试验成功,证明了猪胰岛可以治疗灵长类动物的糖尿病。
1999年,获得卫生部批准,在国际上率先开展了猪胰岛移植治疗人糖尿病的临床研究,22名患者明显好转,胰岛素用量平均减少40%,证明猪胰岛移植的安全性,并具有一定的治疗效果。
2000年,考虑到供体性和标准化是保证胰岛移植糖尿病的安全性和疗效的关健,从全国偏远地区筛选合适的供体猪,并定向近交培养,培养出我国独有和国际领先的胰岛移植用供体猪。
2008年,联合国世界卫生组织充分肯定王维教授团队移植猪胰岛的成果,组织世界各国专家专程到长沙,由中南大学湘雅三医院牵头制定指导联合国各成员国从事异种移植临床研究的规范。
2012年,中南大学组建湖南赛诺生物科技股份有限公司,建立了符合世卫组织标准的异种移植供体猪培育中心,保证了猪胰岛移植的生物安全性。建立了猪胰岛移植糖尿病的技术体系。
2013年,中南大学湘雅三医院和湖南赛诺生物科技股份有限公司在获得政府批准后,开始了新的技术体系下的猪胰岛移植治疗糖尿病临床研究,2017年9月通过专家鉴定,在猪胰岛移植糖尿病领域中取得了国际上最好的治疗效果。
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