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[中国梦实践者]中科院强磁场科学中心八位海归科学家:与世界顶尖选手并跑的人

2017-09-12 07:57:28   中国经济网

  “能用一流实验装置,很幸福”

都不是安徽人,也都未曾在这里念过书,“哈佛八剑客”之所以能够万里迢迢奔赴科学岛工作生活,很重要的是源于强磁场的魅力。

与极低温、超高压一样,作为科学探索利器的强磁场是现代科学实验最重要的极端条件之一,可以使得物质特性发生变化。对强磁场的认知往往伴随着重大的科学发现,自1913年以来,19项与磁场有关的科技成果相继获得诺贝尔奖。

按照既定计划,稳态强磁场实验装置2008年开工建设,建成后中国将成为世界上第五个拥有稳态强磁场装置的国家。在“哈佛八剑客”眼中,随着经济、科技实力的增强,国内的科研环境已经发生了翻天覆地的变化。用“八剑客”的话说,“利用一流的实验装置,在磁共振生命科学领域自由探索,没有什么比这更幸福的事了”。

而且,依托强磁场大科学装置与技术,在分子、细胞、组织、动物模型、人体等多个层次开展重大生命科学研究,他们有着得天独厚的优势:王俊峰、张钠擅长研究蛋白和核酸的结构生物学,张欣负责研究细胞生物学,林文楚重点研究新型的动物模型,刘青松、刘静、王文超和任涛则组成药物学小团队。一个有所区别而又环环相扣的学术链就这样形成了。

撸起袖子加油干,事实印证了他们的选择。刘青松、刘静课题组研究发现,“老药”依鲁替尼可应用于急性髓细胞白血病和非小细胞肺癌的治疗;张欣课题组与大连化物所李国辉课题组合作,在磁场抑制肿瘤细胞生长机制,以及磁场联合化疗药物抑制肿瘤细胞生长方面的研究取得了系列进展,相关研究从实验上证明了稳态磁场在肿瘤治疗方面的潜在应用。

回国后的几年里,“八剑客”已发表学术论文几十篇,其中多篇成果发表在《自然》《科学》等国内外权威知名杂志。“短短几年,这个团队已在国际相关领域初步显现出影响力,很多人的科研成果比在哈佛时还要大。”匡光力如是评价。

  宝剑锋从磨砺出

2009年,强磁场中心还处于第一个五年建设阶段,科研大楼还没完全建好,大部分仪器还未到齐。为了不耽误科研进度,王俊峰一头扎进了破旧的小红楼,开始了夜以继日的实验,就连很多实验器材都是从兄弟单位借的。

不仅“硬件”欠缺,质疑声也一度不绝于耳。几年前,听说刘青松等人要创制新药,一些专家好言相劝:“这事我们都试过了,太难!”“还是老老实实做点基础研究发点文章吧!别搞到最后连团队都养不起。”担忧之声并非毫无理由,药物研发是一个高度学科交叉的工作,从学术界开始进行药物研发以及相关研究,在当时国内不很完善的相关环境下确实颇有难度。

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