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小苏打“饿死”癌细胞? 教授道出了其中奥秘

2016-09-25 07:08:22   兰州日报

浙江大学肿瘤研究所教授胡汛和研究团队一起发现了“饿死”癌细胞的新疗法,并发表在国际生物和医学领域权威杂志elife上,得到了国际著名肿瘤学者的肯定。

“癌细胞也需要‘吃’东西才能生存,剥夺它的食物,癌细胞就会死亡。”胡汛说,就是循着这个看似简单的原理,他和研究团队一起发现了“饿死”癌细胞的新疗法。

经过多年基础研究,胡汛发现葡萄糖是癌细胞必需“吃”的东西,照理看剥夺葡萄糖癌细胞就会死亡。但实际上葡萄糖供应不足时,肿瘤没有饿死还不断生长。

胡汛教授道出了其中奥秘:肿瘤中有大量的乳酸,乳酸解离成乳酸阴离子和氢离子,成为癌细胞的两位“帮手”,让其自身能够根据“食物”的多少决定“消耗”多少。

两位“帮手”协同作用,使得癌细胞在葡萄糖含量很少时,非常节约地利用葡萄糖;在没有葡萄糖的情况下进入“休眠”状态;当有葡萄糖供应时即刻恢复生长状态。

因此,若想有效“饿死”癌细胞,不仅要剥夺葡萄糖,还需同时破坏乳酸阴离子和氢离子的协同作用。在葡萄糖饥饿或缺乏的前提下,只要去除这两个因子中的任何一个,癌细胞就会快速死亡。

研究人员用碱如碳酸氢钠(小苏打)来去除肿瘤内的氢离子,就可破坏乳酸根和氢离子的协同作用,从而快速有效地杀死处于葡萄糖饥饿或缺乏的肿瘤细胞。

责任编辑:李东舰 CN031
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