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研究称寨卡病毒可能导致男性不育
2016-11-22 21:26:40 新华通讯社
原标题:科学家称寨卡病毒可能导致男性不育
新华社北京11月22日电(记者 董瑞丰)科学家最新研究发现寨卡病毒在实验小鼠中可以引起睾丸损伤并最终导致雄性不育,这一发现从新的角度揭示了寨卡病毒影响人类健康的可能性。
国际学术刊物《细胞》北京时间22日在线发表了中国农业大学李向东教授课题组与中国科学院微生物研究所高福院士团队合作的上述研究成果。
寨卡病毒疫情前一时期成为国际关注的公共卫生问题,以往研究者对寨卡病毒的关切主要集中在胎儿异常如流产、新生儿小头症等。2016年5月,有临床杂志报道寨卡病毒能够通过性传播感染,且病毒RNA能够在人的精液中长期存在,提示了这一病毒新的传播途径和对人类健康的潜在威胁。
《细胞》杂志编辑史蒂夫·毛博士说,中国科学家的最新研究找到了寨卡病毒通过精液传播的科学依据,也明确了该病毒通过性传播可能引起的危害。
该研究表明,寨卡病毒可以突破小鼠的血-睾屏障,一旦突破血-睾屏障,在感染后第8天引起睾丸间质充血、急性睾丸炎和附睾炎,睾丸和附睾组织明显萎缩,睾酮水平显著降低;第16天,大量精细胞死亡、睾丸精管断裂逐渐丧失;第30天,睾丸进一步缩小,曲细精管进一步丧失正常结构;第60天,睾丸完全萎缩丧失组织结构。
中科院院士、中国疾病预防控制中心副主任高福说,随着越来越多的临床和基础研究展开,科学家发现寨卡病毒对人类的伤害超过了最初的想象。
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