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浙江贝达医药股份有限公司董事长丁列明:抗癌领域“神枪手”

2017-09-08 18:26:50   中国经济网

当时,我国在抗癌药品研发方面十分落后,药品目录里绝大部分的抗癌药都是仿制药,自主研发的新药寥寥无几。是继续在美国研发还是将技术带回国内寻求发展?一个巨大的决策性问题摆在了丁列明面前。

“是祖国培养了我,现在我具备了研制新药的专业知识,为何不回国为病患雪中送炭,却要为医药发达的美国锦上添花?”此时的丁列明已然下定决心。2002年夏天,丁列明放弃了美国的医生职业,登上了回国的飞机。

16岁那年,丁列明孤身来到杭州,39岁这一年,他再次回到杭州。16岁时,丁列明带着乡村娃的质朴与好奇,39岁时,他带着世界领先的科研成果和炽热的创业激情。

回国后不久,贝达药业成立了。丁列明当时提出了一个口号:做好药,让人民生活得更好。丁列明和团队的第一个产品就是国家一类新药盐酸埃克替尼(凯美纳),这是我国第一个小分子靶向抗癌新药。

“所谓的靶向抗癌,就是在细胞分子水平上,针对已经明确的致癌位点,设计相应的治疗药物,药物进入体内会专门选择致癌位点相应地发生作用,使肿瘤细胞特异性死亡。”丁列明形象地比喻道:“就像射击一样,一枪命中靶心。”

2005年底,丁列明和团队在合成出能对抗肺癌细胞化学物质的基础上,完成了制剂、药学、药效、毒性评估等20多项临床前研究。2006年6月,国家食品药品监督管理局批准凯美纳进入临床试验。这是中国第一个进入临床的化学类靶向抗癌药,丁列明和团队为它起了一个颇有寓意的名字:凯美纳,拉丁文的意思是:肺的健康食品。

2010年6月15日,是丁列明终生难忘的日子。凯美纳临床Ⅲ期试验结果在中国医学科学院肿瘤医院揭晓。

那一天,丁列明没有去现场,而是一个人静静地坐在杭州的办公室,等待着结果的公布。

“叮铃铃”电话声响起,丁列明停顿了几秒钟,“喂……”话筒里传来了公司副总裁谭芬来博士略带湖南口音的普通话:“老丁,酒准备好了吗?……”一阵灼热滚过心头,丁列明感到喉头一阵发酸,他的眼眶湿润了……

一年后,凯美纳获得国家食品药品监督管理局新药证书,成为中国首个具有完全自主知识产权的小分子靶向抗癌创新药。国家“十一五”重大新药创制科技重大专项技术总师桑国卫院士称赞凯美纳的研制成功,是在抗癌药领域让中国从仿制到自主创新的历史性转折。

做国人用得起的抗癌药

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