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英国新发现有望改善肺癌早期诊断和治疗

2019-01-24 12:06:01    新华网

新华社伦敦1月23日电(记者 张家伟)伦敦大学学院发布一项新研究说,通过基因组测序等技术手段,团队找到了一些重要差异特征来判别肺部癌前病变是否会最终发展成肺癌,有助实现这类疾病的早期诊断并提升治疗方案疗效。

肺癌发病前往往在气道上会先出现癌前病变,但据该学院介绍,这类病变最终只有约一半会发展成肺癌,另一半会逐渐消散或保持良性。如何发现这其中的差异,对肺癌诊治具有重要意义。

该学院学者领衔的团队对采集自85名病患的活检样本进行了基因组测序等深入分析,并对病患的状况进行了5年以上长期跟踪,以确认哪些病患发展成了肺癌患者。相关结果已刊登在《自然·医学》期刊上。

团队成功确认了癌前病变的一些重要基因特征,其中包括基因变异、基因表达和染色体不稳定等,这些特征的差异能帮助研究人员更准确辨认哪些病变会发展成肺癌。基于这一研究成果,未来医护人员或许能够在疾病更早期阶段就判断出病患是否需要接受手术。

报告作者之一、伦敦大学学院学者山姆·简斯教授说,梳理出癌变前这些细胞内部发生了什么变化,有助人们理解肺癌早期阶段的发展,且研究人员也有可能利用这些信息开发出新的肺癌筛查技术以及新疗法。

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