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澳研发新药对抗肠道“超级细菌”

2019-01-21 21:35:59    新华网

新华社北京1月21日电 澳大利亚弗林德斯大学日前宣布,该校研究人员研发出一种新型抗生素,动物实验表明它可有效抑制一种具有耐药性的肠道“超级细菌”。

细菌通过多种形式“抵抗”抗菌素,逃避被消灭的危险,这种抵抗作用被称为“细菌耐药”。而超级细菌指对多种抗生素都有耐药性的细菌,病人感染超级细菌后缺乏有效治疗药物。据世界卫生组织统计,每年全球约70万人死于超级细菌等耐药菌感染。

“艰难梭状芽孢杆菌”是一种可导致大肠感染的细菌,已逐渐对传统抗生素产生耐药性变异,因此也是一种“超级细菌”,它常见于长期服用抗生素的人群中。这种细菌分泌出的毒素会严重破坏肠道,威胁患者生命。弗林德斯大学的研究团队在新一期英国《科学报告》杂志上报告说,他们研发出一种名为Ramizol的新型抗生素,把它注射到感染了致命剂量“艰难梭状芽孢杆菌”的仓鼠体内后,结果发现很大一部分仓鼠能存活下来。

在另一项评估药物安全性的研究中,研究人员连续14天向48只大鼠注射高剂量的Ramizol。结果显示,没有大鼠出现严重的副作用或体重变化。

研究人员说,这表明Ramizol对动物而言是一种耐受性良好的抗生素。另外,Ramizol具有良好的抗氧化性能和较高的化学稳定性等,且制造成本低,有望应用于人类。

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