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俄罗斯:新型抗甲型流感病毒复合物研发成功

2018-12-25 06:00:00    科技日报

俄罗斯托木斯克理工大学与俄罗斯卫生部斯莫罗金采夫流感研究所共同开发出11种新的siRNA(小干扰RNA),这些siRNA在体外具有抗病毒活性,能在NS、PA和NP基因上抑制甲型流感病毒。通过筛选抗病毒特性,研究人员选择出了最具有抑制能力的三种siRNA:PA-1630,NP-717和NS-777成分。它们的组合是一种新型的抗甲型流感病毒复合物。将这三种针对病毒基因的siRNA封装到杂化聚合物电解质微胶囊中,可用于开发预防和治疗病毒感染的药物。

研究人员比较了含这三种siRNA复合物的微胶囊体外抑制流感病毒的情况,结果显示,含有三种包封的siRNA复合物对H1N1、H5N2、H7N9甲型流感病毒具有很好的抑制作用。

托木斯克理工大学化学生物医学技术研究院研究员亚历山大·基民说,通过实验比较,结果表明siRNA可以定位并有效地保留在胶囊内,微胶囊可以有效保护siRNA免于降解,这对于在细胞内输送siRNA是必不可少的。如有必要,还可以通过表面改性实现更高的生物相容性目标。

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