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新研究有助尽早识别埃博拉出血热重症者

2017-11-18 18:01:32   新华网

新华社东京11月18日电(记者华义)曾在西非导致严重疫情的埃博拉出血热致死率很高,但也有些患者幸存下来。日本科研人员主导的一项国际合作研究发现了埃博拉出血热死亡患者血液中的一些生物标记,将有助于快速识别并医治重症患者。

日本东京大学医学科学研究所教授河冈义裕等人在美国学术刊物《细胞宿主与寄生体》新一期上报告说,他们所在的国际研究小组曾于2013年到2016年在埃博拉出血热流行的西非国家塞拉利昂进行了调查,对20名患者和10名健康人的血液进行了采样,这20名患者中有9人最终死亡,11人幸存。

对比分析发现,死亡患者体内免疫系统出现异常反应并引起组织功能障碍。和康复患者相比,死亡患者血液中胰酶的量高出约30倍,而一般情况下胰酶主要存在于胰脏里。此外,死亡患者血液中一种蛋白质的量只有康复患者的四分之一到一半。研究人员认为,这些血液中的生物标记有助尽早区分出重症患者。

研究小组认为,这项研究揭示了埃博拉出血热重症化的部分机制,有助于今后发生埃博拉出血热疫情时制定更有效的公共卫生对策。

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