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贝达药业和美国Tyrogenex公司签约 阔步进军全球肿瘤药物市场

2017-08-28 16:31:09   中国经济网

美国东部时间8月25日上午,在美中贸易协会会长JohnFrisbie,原美国癌症中心主任SamuelBroder博士等领导和嘉宾的见证下,贝达药业股份有限公司和美国Tyrogenex公司在华盛顿正式签约,成立合资公司EquinoxSciencesLLC公司(中文名:医科诺生物科技有限公司),积极进军全球肿瘤药物市场。贝达药业董事长兼首席执行官丁列明博士和Tyrogenex公司首席执行官EricRichman代表双方公司签署战略合作协议。

贝达药业与美国Tyrogenex公司签约现场

Tyrogenex公司是一家美国生物制药企业,专注于血管内皮生长因子受体(VEGFR)和人血小板衍生生长因子受体(PDGFR)靶点的湿性年龄相关性黄斑变性和实体瘤药物的开发。Tyrogenex公司在研的X-82(Vorolanib)化合物,是一款针对血管内皮生长因子受体(VEGFR)和血小板衍化生长因子受体(PDGFR)靶点的口服抑制剂,可用于眼科及肾癌、胃癌、肺癌等多种癌症的治疗。新成立的Equinox公司,贝达药业和Tyrogenex公司各占50%的股权,共同开发Vorolanib化合物肿瘤适应症中国区域外的全球权利。对于当天的签约,SamuelBroder给予高度评价,他说,贝达药业与Tyrogenex的合作是一个了不起的决定,对贝达药业的长远发展有着重要意义,实现互利共赢、比翼齐飞。

此前,贝达药业已和Tyrogenex公司达成战略合作,以1000万美元的对价认购Tyrogenex公司新发行的G轮优先股,持有其7%的股份,主要开发Vorolanib化合物眼科适应症中国区域外的全球权利。

“这次贝达药业与Tyrogenex公司再次合作,既是强强联手又是‘亲上加亲’。”丁列明博士说,Vorolanib化合物在中国的项目名称叫CM082,由著名药物化学专家梁从新博士发明,海归博士团队创办的卡南吉医药科技(上海)有限公司,拥有其在中国区域的专利权、开发权、生产权和销售权。今年上半年,贝达药业斥资4.8亿元全面收购卡南吉,拥有CM082项目在中国区域的全部权益。

贝达药业为何对这个项目如此情有独钟?贝达药业资深副总裁兼首席医学官谭芬来博士透露了其中的奥秘。他说,Vorolanib(CM082)是针对VEGFR、PDGFR、c-Kit、Flt-3和CSF1R等多靶点的小分子靶向新药,临床剂型为口服片剂,不但具有针对VEGFR和PDGFR抗血管生成等多靶点的显著疗效,同时克服了这一类靶向药常见的高毒副作用,并且一改同类药物需要进行注射的弊端,未来在眼科、肾癌等领域疾病的治疗中前景广阔。

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