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他回国搞研发 抗癌新药世界领先

2017-09-08 08:56:44   中国青年网

4年前,从美国亚利桑那大学药学院回国的陈中祝博士接受重庆文理学院邀请,开始组建创新靶向药物国际研究院。4年后,团队自主研发的“抗ED和肺动脉高压一类新药”即将进入临床研究,而与美国专家合作研发的治疗甲状腺癌、乳腺癌的RET抑制剂,也属于世界领先水平。

陈中祝出生在安徽怀宁。获得美国亚利桑那大学VPR博士后奖之后,经过慎重考虑,陈中祝最终选择了回国。“跟国外相比,我国目前的新药研发能力还较薄弱,正是需要科研人员的时候,从另一个角度来说,国内新药研发的发展空间会更广阔。”

2015年,陈中祝率领“抗ED和肺动脉高压一类新药”项目研发团队进入“第四届中国创新创业生物医药行业全国总决赛”,以90.58分的成绩,打败了来自众多名校、大型药企和科研机构的200多支全国优秀团队。

目前,“抗ED和肺动脉高压一类新药”已完成临床前安全评估,预计2017年底可进入临床研究。与目前国际销售较好的同类药物相比较,该药物有起效更快、更安全和有较适中的药效时间等明显优势。

此外,团队与美国合作研发的治疗甲状腺癌、乳腺癌的RET抑制剂,与目前甲状腺癌治疗药物相比较,体外活性增加了1000倍以上。

陈中祝说,此药物可同时针对RET和VEGFR2靶向,相当于同时阻断了肿瘤细胞的两条前进路径,在世界上属于领先水平。成功上市后能提高癌症的治疗效果和减少药物的耐药性,给广大癌症患者带来良好的预后。

“做研究,必须耐得住寂寞,静得下心。”一年中除去春节,陈中祝的时间几乎都放在了研究院,每天早上7点多就上班,晚上10点过下班。

2016年,创新靶向药物国际研究院成功获批重庆市级博士后科研工作站。团队先后聘请了6名世界知名新药研发专家作为首席科学家,现在,创新靶向药物国际研究院有科研人员27人,有博士学位的科研人员21人,有海外留学经历的科研人员10人,成为一支不容小觑的国际协同创新新药研发团队。本报记者 林祺

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