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第三代基因测序仪问世

2017-08-05 06:32:26   中国青年网

“80后”南方科技大学生物系副教授、瀚海基因生物科技有限公司董事长贺建奎介绍产品。 本报记者 喻 剑摄

本报讯 记者喻剑报道:日前,南方科技大学在深圳举行“孔雀团队第三代基因测序仪重大成果发布会”,正式推出我国自主研发的第三代基因测序仪GenoCare。这是目前全球准确率最高且唯一用于临床应用的基因测序仪,技术水平达到“亚洲第一、世界领先”,占据基因产业的创新制高点。

据第三代基因测序仪研发人——南方科技大学生物系副教授、瀚海基因生物科技有限公司董事长贺建奎介绍,GenoCare取得关键性突破,能够直接读取最原始的DNA或RNA分子序列,降低临床基因测序成本。其核心技术为单分子荧光测序,通过全内反射荧光成像方法,能够检测单个荧光分子,无需聚合酶链式反应(PCR)扩增。

“我们的方法是,把背景变黑,就如让人在黑夜中轻松找到那只发着微光的萤火虫。”贺建奎说。这项技术简化了步骤,未来样品处理仅需不到半小时,且无需专门的建库实验员和场地。此外,GenoCare规避了PCR扩增引入的错误,提高了灵敏度,临床应用将大有可为。

经历5年艰苦攻关,目前,贺建奎团队已完成三代测序仪和配套试剂的全部研发,并完成小批量样机生产,接下来将会大批量投产,实现三代测序仪的国产化。截至目前,研发团队已取得专利92件。

据介绍,第一代基因测序仪完成一个人的全基因组价格是30亿美元,“一个人测一次基因序列相当于建了一艘航母”;第二代基因测序仪测一个人的全基因组价格降至1000美元;第三代基因测序仪量产后,这一测序价格有望降到100美元,低廉的价格将帮助每个人打造专属“基因身份证”。

中国科学院院士陈润生认为,“人类遗传密码解析的进展,将会载入人类生物医学发展史册。测序仪就是解析人类遗传密码核心的、不可或缺的设备”。GenoCare的亮相,极大提升了基因测序效率,让中国三代基因测序技术与美国、英国形成“三足鼎立”之势。

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