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英国科学家首次在实验室培育出人类骨骼,有望在不久的将来用于骨科医学。
格拉斯哥大学、斯特拉思克莱德大学、西苏格兰大学和高尔韦大学的研究人员把志愿者捐献的间充质干细胞悬浮在胶原凝胶中。间充质干细胞由人体骨髓产生,可以分化成软骨、韧带、筋、脂肪和骨骼等。随后,研究人员借助纳米反冲技术,每秒产生大约1000次的纳米级振动,把胶原凝胶中的细胞变成3D骨细胞。这些骨细胞将来可以植入患者,修复或替代受损的骨骼部分,治疗骨折、填补髋关节和膝关节置换术后的骨骼间隙等。鉴于使用的是患者自身的间充质干细胞,不易发生排斥,从而能够填补更大的骨骼间隙。
骨骼是主要移植组织之一,主要用于重建、矫形等手术。当前,医生只能从患者自身获得有限的活骨用于移植,不仅会增加患者手术痛苦,还容易发生感染;而他人的骨骼容易遭排斥。
研究报告刊载于最新一期英国《自然·生物医学工程》杂志。研究人员在报告中写道,将于2020年进行首项人体试验。(黄敏)【新华社微特稿】
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