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加拿大麦基尔大学的研究人员说,如果难以分辨是泡泡糖味还是汽油味,那得小心老年痴呆症了,嗅觉变化或是阿尔兹海默氏症的先兆之一。
研究人员征募了300名阿尔兹海默氏症高风险人士,他们的父母中有一人罹患这一疾病。研究人员让志愿者做一系列嗅觉测试,分辨多种强烈气味,比如泡泡糖味、汽油味和柠檬味等。随后,其中100人自愿做常规腰椎穿刺,检测脑脊髓液中与阿尔兹海默氏症相关的多种蛋白质的数量。结果显示,分辨气味最困难的志愿者,体内阿尔兹海默氏症生物指标最高。
英国《每日电讯报》16日援引研究人员的话报道,这是首次明确显示,失去分辨气味能力关联阿尔兹海默氏症发病的生物指标。
研究人员认为,嗅觉测试可以作为一种简便快速、成本低廉的阿尔兹海默氏症检测法,有助尽早实施干预。这种疾病目前尚无有效疗法,多数科学家认为,这可能是因为出现明显痴呆症症状时才给药为时过晚,已经无法修复损伤。
研究结果刊载于美国《神经学》周刊。(黄敏)【新华社微特稿】
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