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免疫细胞“休眠”导致类风湿性关节炎长期发作

2017-08-14 11:21:40   新华网

新华社北京8月14日电 一个国际科研团队近日发现,类风湿性关节炎之所以长期难以痊愈,与一种免疫细胞处于“休眠”状态有关。

德国埃尔朗根—纽伦堡大学发布的新闻公报说,这一发现由该校研究人员与多国同行共同取得,将为治疗类风湿性关节炎提供新思路,可望显著提高患者的生活质量。

类风湿性关节炎是一种常见的自身免疫疾病,患者免疫系统错误地攻击自身关节,导致炎症。正常情况下人体炎症会自行缓解,但类风湿性关节炎患者的炎症长期无法消退。

新研究显示,一种被称为固有淋巴细胞的免疫细胞起着调节作用,对炎症消退很重要。在实验鼠体内,该细胞“休眠”会导致关节出现慢性炎症,骨骼和软骨严重受损;“唤醒”该细胞会启动一套分子机制,促使自身免疫系统重新发挥作用,使炎症缓解。

相关论文发表在英国《自然·医学》杂志上。研究人员说,针对固有淋巴细胞开发新的消炎手段,可以取代免疫抑制疗法,避免后者带来的副作用。

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