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新研究用诱导多能干细胞制成免疫细胞

2018-05-26 11:11:05   新华网

新华社东京5月26日电(记者华义)日本一个研究团队最新宣布,他们利用诱导多能干细胞(iPS细胞)成功培养出了一种辅助性免疫细胞。研究人员认为,这一成果有望应用于治疗癌症。

免疫细胞中有负责攻击癌细胞等的“杀手T细胞”,还有负责发出攻击命令的“辅助性T细胞”。而诱导多能干细胞是将成体细胞重编程后获得的,它像胚胎干细胞那样拥有发育成各种组织的能力。

日本京都大学诱导多能干细胞研究所的一个团队说,他们利用健康人的血液细胞培养出了可以识别白血病细胞抗原的诱导多能干细胞,并通过导入特定基因,进一步培养出了类似“辅助性T细胞”的细胞,试管实验和实验鼠实验都显示,它能够激活“杀手T细胞”,从而发起对白血病细胞的攻击。

癌症患者免疫功能下降被认为是癌细胞增殖的一大原因。治疗癌症的一种新思路是,利用诱导多能干细胞培养免疫细胞并移植给患者。研究小组认为,这项新成果有助于此类癌症免疫疗法的开发和应用。

相关论文已发表在美国《干细胞报告》杂志网络版上。

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