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中国医生研究肺癌新亚型治疗取得成果

2018-04-18 17:11:10    新华网

新华社广州4月18日电(记者 胡林果)国际医学杂志《临床肿瘤学》近日发表了广东省人民医院副院长吴一龙团队的研究成果。该研究成果显示,使用克唑替尼对c-ros肉瘤致癌因子-受体酪氨酸激酶(ROS1)阳性晚期非小细胞肺癌的治疗有效率达72%。

据吴一龙介绍,ROS1阳性非小细胞肺癌是一种独特分子亚型,这一基因突变导致的肺癌患者约占非小细胞肺癌患者的1%–2%。“找驱动基因,针对这些驱动基因,医院可进行靶向治疗。”

吴一龙说,“哪些病人可以受益于靶向药物治疗,需要使用某些试剂产品进行测试,这个过程就叫伴随诊断。”

吴一龙团队通过有效的伴随诊断,从超过1000名来自亚洲地区的患者中筛选出127名ROS1阳性非小细胞肺癌患者,并采用克唑替尼进行治疗,结果一半以上的晚期患者维持疾病不恶化时间达16个月,13%的患者肿瘤消失,还有三分之一的患者仍在接受治疗。

该研究团队采用了中国企业研发的诊断试剂盒进行筛选,并通过临床试验,证实了使用克唑替尼治疗ROS1阳性非小细胞肺癌的有效性。

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